Since 2015, the LOD Conference brings academics, researchers and industrial researchers together in a unique multidisciplinary community to discuss and present the state of the art and the latest advances in the integration of machine learning, optimization and data science to provide the scientific and technological foundations for interpretable, explainable and trustworthy AI. Since 2017, LOD adopted the Asilomar AI Principles. The 6th Annual Conference on machine Learning, Optimization and Data science (LOD) is a international conference on machine learning, computational optimization and big data that includes invited talks, tutorial talks, special sessions, industrial tracks, demonstrations and oral and poster presentations of refereed papers. LOD has established itself as a premier multidisciplinary conference in machine learning, computational optimization and data science. It provides an international forum for presentation of original multidisciplinary research results, as well as exchange and dissemination of innovative and practical development experiences.